The role of NEDD4-mediated ubiquitination of AQP5 in allergic rhinitis: implications for nasal mucosal barrier function
BackgroundAllergic rhinitis (AR) pathology is mainly due to disruption of the nasal epithelial barrier, but the role of aquaporin 5 (AQP5) is not fully understood. We propose that the E3 ubiquitin ligase NEDD4 is responsible for the degradation of AQP5…