Salidroside targets the Notch1/Hes5 axis to reconstruct the molecular innate immune–vascular network and correlates with repair after ischemic stroke

BackgroundIschemic stroke (IS) induces profound dysregulation of the neuro–molecular innate immune–vascular network, yet the molecular immune states and regulatory mechanisms of key cellular subpopulations remain insufficiently defined. Although tradit…

Immune microenvironment heterogeneity characterizes biologically distinct KRASmut/SPOPmut and KRASmut/PIK3CAmut mesonephric-like adenocarcinoma subtypes revealed by integrated whole-exome and transcriptomic profiling

ObjectiveThis study aims to uncover the molecular biology and immune microenvironment of gynecological mesonephric-like adenocarcinoma (MLA).MethodsTo determine the comprehensive characteristics of MLA, 17 patients with MLA were retrospectively enrolle…

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