An IHC-derived TLS–CD8–macrophage immune niche score predicts major pathological response to neoadjuvant chemoimmunotherapy in resectable NSCLC

BackgroundNeoadjuvant chemoimmunotherapy improves pathological response in resectable non-small cell lung cancer (NSCLC), but response remains heterogeneous. PD-L1 tumor proportion score (TPS) incompletely captures spatial immune contexture. We develop…

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