Sex-based heterogeneity in response to first-line immunotherapy plus chemotherapy in advanced esophageal squamous-cell carcinoma: a meta-analysis

ObjectiveAmid acknowledged sex-based disparities in immune system response, the effect of patients’ sex on the efficacy of immune checkpoint inhibitors (ICIs) treatment remains inconsistent across cancers, and even inconclusive in esophageal squamous-c…

Multi-omics integration identifies ASPH and PTTG1 as potential causal drivers of lung adenocarcinoma progression and immune evasion

BackgroundDespite advances in therapy, lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality. Angiogenesis and immune evasion critically influence LUAD progression and treatment resistance, yet epithelial-derived regulatory mechanisms …

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