BackgroundThe therapeutic landscape of advanced hepatocellular carcinoma (HCC) has expanded beyond sorafenib, with multiple combination regimens now demonstrating improved outcomes. However, the absence of direct head-to-head comparisons complicates tr…
ObjectivesNeutrophil extracellular traps (NETs) are a crucial mechanism of the neutrophil immune response and exhibit complex dual pathological and physiological effects in pulmonary diseases. In recent years, this research domain has increased signifi…
BackgroundChronic hepatitis B virus (HBV) infection represents a major global public health issue, affecting hundreds of millions worldwide and serving as a primary cause of cirrhosis and hepatocellular carcinoma. In recent years, immunotherapies aimed…
ObjectiveNeuropsychiatric systemic lupus erythematosus (NPSLE) is a severe and complex complication of systemic lupus erythematosus that affects diagnostic decision-making and treatment strategies. However, the temporal evolution of evidence-based diag…
BackgroundImmune checkpoint inhibitors (ICIs) are widely used in lung cancer treatment; however, immune-related adverse events (irAEs) remain an important safety-related research topic. Currently, there is a lack of comprehensive bibliometric analyses …
ObjectiveTo evaluate the efficacy and safety of programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) inhibitors combined with chemotherapy as first-line treatment for advanced or metastatic endometrial cancer.MethodsA systematic literature search …
BackgroundPatients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) remain at residual cardiovascular risk. The pan-immune-inflammation value (PIV), integrating neutrophil, platelet, monocyte, and lymphocyte counts…
BackgroundInflammatory bowel disease (IBD) is a chronic condition characterized by recurrent inflammatory episodes in the gastrointestinal tract. Conventional therapies, including biologics, corticosteroids, and immunosuppressive drugs, can effectively…
BackgroundInfluenza infection is an important trigger of acute cardiovascular events and respiratory decompensation in vulnerable populations. Although influenza vaccination may reduce cardiopulmonary morbidity and mortality, the overall certainty and …
BackgroundMicronutrient deficiencies are common in the older adults and exacerbate these changes. Micronutrient supplementation has been proposed as a method to reverse immunosenescence. However, its effectiveness has been inconsistent. This systematic…
