BackgroundAutoimmune encephalitis (AE) encompasses a highly heterogeneous spectrum of severe immune-mediated neurological disorders. Over the past 50 years, research has expanded rapidly, yet a quantitative synthesis of its evolution, key contributors,…
BackgroundHepatocellular carcinoma (HCC) is a highly prevalent and lethal malignancy worldwide, with its incidence steadily rising over recent decades. Conventional treatments, including chemotherapy, surgery, immunotherapy, Targeted Therapy and radiot…
IntroductionThe impact of Helicobacter pylori (H. pylori) on the gastrointestinal tract ecosystem has been widely investigated beyond the stomach. Researchers have made considerable progress in understanding the relationship between H. pylori infection…
ObjectiveTo comprehensively summarize risk factors and explore potential mechanisms associated with cutaneous immune-related adverse events (cirAEs) in cancer patients treated with immune checkpoint inhibitors (ICIs).MethodConducted in accordance with …
BackgroundThe first-line treatment for persistent, recurrent, or metastatic cervical cancer continues to pose significant clinical challenges. While the application of immune checkpoint inhibitors (ICIs) has transformed the existing treatment paradigm,…
BackgroundSystemic lupus erythematosus (SLE) is a complex autoimmune disease in which patients have a significantly increased risk of developing osteoporosis (OP) and osteopenia. Despite numerous studies, the global burden of SLE-related OP, its region…
BackgroundThe development of rapidly progressive interstitial lung disease (RP-ILD) in patients with anti-MDA5-positive dermatomyositis-associated interstitial lung disease (MDA5+ DM-ILD) is a major cause of adverse outcomes, including mortality. This …
IntroductionIndividuals with Sjögren’s syndrome (SjD) experience notable health challenges, including chronic pain, fatigue, and depression; however, the potential benefits of physical activity in alleviating these issues remain unclear. We aim to syst…
BackgroundRheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic inflammation, posing a high risk of death, particularly from cardiovascular events. Finding simple and cost-effective prognostic biomarkers is crucial for ri…
BackgroundCD276 (B7-H3) is a pivotal immune checkpoint molecule with dual roles in T-cell regulation and tumor immune evasion, representing a promising therapeutic target across multiple cancers. However, a comprehensive analysis of the research landsc…
