Extracellular caspase-1: a critical inducer and a therapeutic target of lung injury in gut ischemia-reperfusion
Caspase-1 is known to function intracellularly. However, whether caspase-1 can be released extracellularly and if so, the mechanisms of its release and action remain unknown. Here, we identify that cleaved caspase-1 (p20), which we named extracellular …