Kunal R. More – InmunoES

Structure-based minimization of a high-mobility group protein B1 (HMGB1) B box peptide uncouples anti-NETotic activity and anti-biofilm function

16 de October de 2026 by Kunal R. More

IntroductionWe previously showed that human HMGB1 has anti-biofilm activity localized to a 97-amino-acid B-Box-derived peptide (mB Box-97), engineered with a C106S mutation to reduce HMGB1’s proinflammatory properties while retaining anti-biofilm funct…

High-mobility group protein B1 derived mutant peptide mB Box-97 inhibits the formation of neutrophil extracellular traps

22 de April de 2025 by Kunal R. More

IntroductionNeutrophil Extracellular Traps (NETs) are vital for innate immunity, playing a key role in controlling pathogen and biofilm proliferation. However, excessive NETosis is implicated in autoimmunity, inflammatory and neoplastic diseases, as we…