Luigi Fiore – InmunoES

Human macrophages activate a coordinated program linking inflammation and cell death in response to intracellular Poly(I:C)

2 de October de 2026 by Luigi Fiore

BackgroundMacrophages sense viral double-stranded RNA (dsRNA) via the innate immune receptors TLR3 and MDA5 whose activation drives a robust inflammatory program, often coupled to cell death. TLR3/TRIF-dependent apoptosis has been described in response…

Human neutrophils recognize group B streptococci via formylated peptide receptors and toll-like receptor 8

4 de May de 2026 by Luigi Fiore

IntroductionNeutrophils, the most abundant leukocyte population, play a central role in host defense against group B Streptococcus (GBS), an encapsulated bacterium that frequently causes severe infections in humans, including sepsis and meningitis. How…