Enhancing tuberculosis vaccine efficacy with a heterologous mRNA-ChAdOx1 prime-pull strategy targeting lung-resident memory T cells
IntroductionTuberculosis (TB) remains a leading cause of morbidity and mortality worldwide, and Bacillus Calmette–Guérin (BCG) offers inconsistent protection against adult pulmonary TB. We previously showed that homologous mRNA vaccination encoding the…