Tranexamic acid inhibits group A streptococci–mediated fibrinolysis in vitro and modulates host immune cells in vivo
Group A Streptococcus (GAS) exploits the host fibrinolytic system by activating plasminogen via streptokinase, promoting clot degradation, tissue invasion, and immune evasion. Tranexamic acid (TXA), a clinically used antifibrinolytic agent, inhibits fi…