Computational analysis of CD40L missense variants A123E, S222F, and G257R predicts altered CD40 binding and trimeric stability in X-linked hyper-IgM syndrome
IntroductionCD40L (CD154) is a homotrimeric member of the TNF superfamily protein expressed on activated CD4+ T cells whose interaction with CD40 is required for class-switch recombination, somatic hypermutation, and B cell terminal differentiation. Lo…