Vitamin C enhances cytotoxicity of CAR-and εTRuC-engineered γδ T cells and modulates Ca2+, NFAT, NF-κB and ERK signaling in human γδ T cells
γδ T cells have raised interest as effector cells in cancer immunotherapy, due to their broad and HLA-independent reactivity towards multiple tumor entities. Despite promising ongoing clinical studies, there is a need to improve the effector function a…