Bioelectronic modulation of the thymic “genetic mirror”: 448 kHz radiofrequency stimulation as a novel strategy for immune tolerance induction in type 1 diabetes
BackgroundType 1 Diabetes Mellitus (T1DM) arises from a fundamental breakdown of central immune tolerance within the thymus. Medullary thymic epithelial cells (mTECs) express the Autoimmune Regulator (AIRE) protein, which drives the promiscuous transcr…