ACSL4 as a context-dependent metabolic switch in hepatocellular carcinoma: implications for ferroptosis and immunotherapy
Hepatocellular carcinoma (HCC) is characterized by profound lipid metabolic rewiring that supports tumor growth, therapeutic resistance, and immune evasion. Among lipid metabolic regulators, acyl-CoA synthetase long-chain family member 4 (ACSL4) has em…