Platelet-rich plasma-derived microRNA let-7a-5p alleviates knee osteoarthritis by regulating macrophage polarization and improving inflammatory microenvironment
BackgroundKnee osteoarthritis (KOA) is closely associated with an imbalance in macrophage M1/M2 polarization within its inflammatory microenvironment. Platelet-rich plasma (PRP) has demonstrated therapeutic efficacy in KOA. Moreover, microRNAs (miRNAs)…