Rahul Mittal Immunology has traditionally interpreted tissue pathology through models centered on immune-mediated cytotoxicity. In this prevailing model, functional decline is considered a downstream consequence of cell death and irreversible loss of cellular mass….
Type 1 diabetes (T1D) has historically been framed as a disease initiated and maintained by dysregulated immunity that targets insulin producing β-cells. However, recent findings from human tissue analysis, single cell transcriptomics, and longitudinal…
Type 1 diabetes (T1D) is an autoimmune disease characterized by the progressive destruction of pancreatic β-cells, leading to insulin deficiency and chronic hyperglycemia. While immune-mediated mechanisms of β-cell destruction are well-recognized, emer…
