Despite major advances in lipid-lowering therapy and stent technology, a substantial proportion of patients undergoing contemporary percutaneous coronary intervention (PCI) experience recurrent major adverse cardiovascular events (MACE) driven by persi…
Obesity drives cardiovascular disease primarily through chronic meta-inflammation, yet the precise molecular convergence linking nutrient excess to sustained NLRP3 inflammasome activation in macrophages has remained unclear. Obesity induces inhibitory …
Diabetic neuropathy (DN) is the most prevalent and debilitating complication of diabetes, with a notable absence of effective disease-modifying therapies in clinical practice. This article proposes a shift in the pathological progression of DN from foc…
Type 1 diabetes (T1D) has historically been framed as a disease initiated and maintained by dysregulated immunity that targets insulin producing β-cells. However, recent findings from human tissue analysis, single cell transcriptomics, and longitudinal…
Cholera has re-emerged as a major global public health threat. Orally administered attenuated or inactivated vaccines offer protection against enteric pathogens such as Vibrio cholerae, and several World Health Organization-prequalified oral cholera va…
The chemokine CXCL12 and its receptor CXCR4 play context-dependent roles in hair follicle biology. While recent findings suggest that regulatory T cells (Tregs) utilize the CXCL12–CXCR4 axis to modestly promote hair follicle regeneration under homeosta…
Prediabetes affects a significant portion of the global population. Shifting the clinical paradigm from delaying type 2 diabetes (T2D) to actively achieving remission offers a transformative opportunity. This perspective article posits that anti-inflam…
Chronic hepatitis B (CHB) remains a significant global health issue, particularly in children, where the virus can lead to long-term hepatic damage and immune system dysregulation. Interferon (IFN) therapy, such as pegylated interferon (PEG-IFN), has s…
Complement-dependent cytotoxicity (CDC) results from cell lysis induced by the membrane attack complex (MAC), a pore-forming structure assembled at the terminal stage of the complement cascade that disrupts membrane integrity and causes osmotic cell de…
Complement-dependent cytotoxicity (CDC) results from cell lysis induced by the membrane attack complex (MAC), a pore-forming structure assembled at the terminal stage of the complement cascade that disrupts membrane integrity and causes osmotic cell de…
