Single-cell lineage tracing in tumor organoids identifies expansion states depicting the origin and progression of lung adenocarcinoma
IntroductionOnly a subset of epithelial cells can initiate progressive lung adenocarcinoma (LUAD), yet the founder cell states that confer this competence remain poorly defined.MethodsWe established a barcoded KrasG12D, Trp53 loss mouse LUAD organoid m…