Contrasting relapse rate associated with the absence of HLA-A3/A11 in T cell-replete haploidentical transplantation

IntroductionNatural killer cell alloreactivity contributes to the graft-versus-leukemia (GVL) effect of haploidentical hematopoietic stem cell transplantation (haplo-HSCT). However, its importance remains controversial across studies.MethodsIn this ret…

Prediction and effect on relapse of natural killer cell alloreactivity based on KIR-HLA interactions in pediatric haploidentical transplantation with anti-thymoglobulin

IntroductionRelapse continues to be a major factor contributing to therapeutic failure in haploidentical hematopoietic stem cell transplantation (HSCT). The role of natural killer (NK) cell alloreactivity mediated by killer immunoglobulin-like receptor…

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