Xiaofang Xu – InmunoES

IRF1 mediates airway epithelial innate memory through priming BRD4- EP300 activity

28 de July de 2026 by Xiaofang Xu

IntroductionSentinel cells of the airway epithelium are repetitively exposed to RNA virus infections. Here, the production of pathogen-associated molecular patterns (PAMPs) activates the innate immune response (IIR), inducing antiviral defenses, activa…

Cooperative interaction of interferon regulatory factor -1 and bromodomain—containing protein 4 on RNA polymerase activation for intrinsic innate immunity

27 de March de 2024 by Xiaofang Xu

IntroductionThe human orthopneumovirus, Respiratory Syncytial Virus (RSV), is the causative agent of severe lower respiratory tract infections (LRTI) and exacerbations of chronic lung diseases. In immune competent hosts, RSV productively infects highly…