Deciphering hub genes and immune landscapes related to neutrophil extracellular traps in spinal cord injury: insights from integrated bioinformatics analyses and experiments

BackgroundSpinal cord injury (SCI) is a debilitating neurological condition that results in severe motor, sensory, and autonomic dysfunction, imposing a considerable burden on affected individuals and healthcare systems. Neutrophil extracellular traps …

Methyl-CpG-binding domain protein 2 epigenetically represses monocyte HLA-DR expression and promotes immune paralysis in HBV-related acute-on-chronic liver failure

Chronic hepatitis B (CHB) is the leading cause of acute-on-chronic liver failure (ACLF) in China and other Asian countries. A defining immunopathological feature of hepatitis B virus-related ACLF (HBV-ACLF) is immune paralysis, which significantly incr…

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