Xichao Ou
Safety, tolerability, and concordance with interferon-γ release assays of a recombinant ESAT6–MPT64 skin test: a phase 1 randomized clinical trial
BackgroundAccurate and cost-effective screening for Mycobacterium tuberculosis (Mtb) infection remains a global challenge. While Interferon-γ Release Assays (IGRAs) offer high specificity, their widespread deployment is hindered by high costs and techn…
Screening and preclinical assessment of novel Mycobacterium tuberculosis recombinant antigens based tuberculin skin testing
IntroductionA new class of Mycobacterium tuberculosis (MTB) antigen-based skin tests was recommended by WHO for the diagnosis of TB infection. However, their performance in some settings remains suboptimal. Our study focused on screening novel MTB reco…