Xuemei Li Cellular & Molecular Immunology, Published online: 04 March 2026; doi:10.1038/s41423-026-01391-1Lytic IFNγ is stored in cytotoxic granules and coreleased with granzyme B to mediate cytotoxic T lymphocyte killing
As a key functional component of the tumor microenvironment (TME), the intratumoral microbiome in colorectal cancer (CRC) has revolutionized the traditional paradigm of the “sterile tumor.” Far from being mere “bystanders,” these intratumoral microbes …
Mesenchymal stem cells (MSCs) hold promise for regenerative medicine due to their unique biological properties, including self-renewal and multi-lineage differentiation potential. Conventional two-dimensional (2D) culture systems may hinder therapeutic…
BackgroundKawasaki disease (KD) is the primary cause of acquired heart disease in children. Intravenous immunoglobulin (IVIG) is the first-line therapy for KD; however, IVIG resistance can occur. Reliable treatment efficacy prediction tools for Chinese…
Irritable bowel syndrome (IBS) is a common disorder of gut–brain interaction, and its pathogenesis remains unclear. Dysbiosis of the gut microbiota is associated with IBS. The gut microbiota may modulate IBS symptoms via the epithelial barrier, mucosal…
