Yao Chen
Impaired NLRP3 inflammasome activation by chitin underlies refractory chromoblastomycosis caused by Fonsecaea pedrosoi muriform cells
IntroductionMacrophage NLRP3 activation is crucial for antifungal immunity, yet its role in chromoblastomycosis—a chronic subcutaneous mycosis typically caused by Fonsecaea pedrosoi—remains unclear. Unlike prior self-resolving models using conidia and …
Macrophage migration inhibitory factor–CD74 axis drives vascular smooth muscle cell–induced M1 macrophage polarization to exacerbate intracranial aneurysm inflammation
BackgroundIntracranial aneurysms (IAs) develop and progress through pathological processes, including inflammation and abnormal changes in the vascular structure. The cytokine Macrophage Migration Inhibitory Factor (MIF) is implicated in the pathology …