Soluble fermentable dietary fiber attenuates age-related cognitive impairment via neuroimmune and antioxidant modulation: evidence from multilevel analyses in populations and aging mouse models

BackgroundAge-related cognitive impairment (ARCI) is an urgent public health concern with limited therapeutic options. Soluble fermentable dietary fiber (SFDF) is a safe, accessible nutritional factor that may support cognition through microglial remod…

Xrcc6 coordinates cardiomyocyte repair and immune regulation in myocardial ischemia-reperfusion injury: Fisetin as a therapeutic modulator

IntroductionMyocardial ischemia-reperfusion (I/R) injury remains a major challenge in the treatment of ischemic heart disease. The DNA damage repair gene Xrcc6 has been implicated in cardiovascular pathology, but its role in myocardial I/R injury and i…

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