Mitochondrial damage and IL-1β production in monocytes caused by Neospora caninum infection are mediated by dense granule protein 7 and prohibitins

IntroductionThe intracellular proliferation of Neospora caninum tachyzoites and the host immune response against infection are key steps in the pathogenesis of neosporosis. However, the molecules responsible for the activation of the inflammasome induc…

Modified recombinant collagen-peptide/gallic acid grafted chitosan composites with antibacterial and antioxidant property for wound dressing: a preliminary study

Chronic wounds pose a persistent clinical challenge, primarily due to prolonged bacterial infections. The development of natural antibacterial dressings offers a promising strategy for their effective management. In this study, recombinant human collag…

CDK2 inhibition sensitizes anthracycline-induced immunogenic cell death and enhances the efficacy of anti-PD-1 therapy

IntroductionCDK2 (Cyclin-dependent kinase 2) is an oncogenic cyclin-dependent kinase with potent mitogenic and immunosuppressive functions. Despite extensive research on CDK2 inhibitors, the lack of selectivity has made it unclear whether CDK2 inhibiti…

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