Enhancing the tumoricidal efficacy of the nanobubbles-mediated PD-L1 inhibition and immunogenic cell death in mice

BackgroundImmunotherapy becoming the focus of contemporary multidisciplinary collaborative research efforts towards advanced hepatocellular carcinoma (HCC).ObjectiveThis study aims to develop a nanobubble (NB) delivery system designed to co-administer …

Conventional and non-conventional antigen-binding sites promote the development and function of chronic lymphocytic leukemia stereotyped subset #4 clones

Immunoglobulins (IGs) made by chronic lymphocytic leukemia (CLL) B cells are unique in that they bind themselves (homo-dimerize). This interaction leads to signal transduction with functional consequences that depend on the affinity of homo-dimerizatio…

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