Precise delivery and controlled release: strategies and advances in TLR7/8 agonist prodrugs for cancer immunotherapy
Toll-like receptor 7/8 (TLR7/8) agonists (such as resiquimod-R848) are potent immune adjuvants. However, their clinical use is limited by severe systemic toxicity. To address this challenge, prodrug strategies have emerged as a key solution. In recent …