Targeting the oxidative stress-neuroinflammation axis: the mechanism of arctigenin’s broad-spectrum analgesia with limited side effects

BackgroundArctigenin (AG), a natural lignan compound, has been reported to reveal its anti-inflammatory effects in glucose, lipid metabolism and type 2 diabetes mellitus. An increasing number of studies suggest that microglia activation evoked neuroinf…

Role of tumor mutational burden in patients with urothelial carcinoma treated with immune checkpoint inhibitors: a systematic review and meta-analysis

BackgroundThe predictive value of tumor mutation burden (TMB) on the efficacy of immunotherapy has been confirmed in multiple cancer types in previous studies. For urothelial carcinoma (UC) patients treated with immune checkpoint inhibitors (ICIs), whe…

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