Alveolar macrophages (AMs), the resident immune cells of the lung, play a critical role in maintaining pulmonary homeostasis, in part through the secretion of suppressor of cytokine signaling 3 (SOCS3)—a recognized tumor suppressor—within extracellular…
IntroductionNeuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the central nervous system often associated with aquaporin-4-immunoglobulin-G (AQP4-IgG), which activate the complement system, and it can lead to progressive neurol…
IntroductionThe manipulation of the gut microbiota of disease vectors has emerged as a new approach to use in the integrated control of vector-borne diseases. For this purpose, a deep knowledge of their gut microbial communities is essential. To our kn…
ObjectiveTo assess the safety profile of administering intrathecal (IT) chemotherapy concurrently with blinatumomab in pediatric patients with acute lymphoblastic leukemia (ALL).MethodsThis retrospective analysis included 93 pediatric ALL patients trea…
IntroductionAnti-CD20 therapy is an effective steroid-sparing option for pediatric idiopathic nephrotic syndrome (INS), but long-term data on immune reconstitution are limited.MethodsThirteen pediatric INS patients (7 males) were longitudinally evaluat…
ObjectiveTo deepen understanding of the correlation between intracranial tumor and serum myelin oligodendrocyte glycoprotein immunoglobulin G (MOG-IgG) positivity, emphasizing the importance of avoiding misdiagnosis.MethodsWe report a case involving a …
Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are blistering disorders mediated predominantly by IgG1 and IgG4 antibodies directed towards desmoglein (Dsg)1 and/or 3. The anti-CD20 monoclonal antibody rituximab is a highly effective treatment fo…
Mosquitoes rely exclusively on blood-derived sterols, transported by sterol carrier protein (SCP), for reproduction and metabolic regulation. SCP expression is strongly induced after blood feeding and dynamically modulated during Plasmodium vivax infec…
BackgroundRefractory idiopathic nephrotic syndrome (INS), in native kidneys or post-transplant, represents a major therapeutic challenge due to its high risk of progressing to end-stage renal disease. Patients often resist anti-CD20 therapy and require…
ObjectiveVEXAS syndrome (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) is a late-onset autoinflammatory disorder caused by somatic mutations in the UBA1 gene. It is characterized by systemic inflammation, a wide spectrum of rheumatologic fe…
