Primary immune regulatory disorders are a newly coined term for a group of disorders in which autoimmune complications predominate. Herein, we present a case series of 26 patients with various regulatory T-cell (Treg) pathway defects who presented with…
Culture conditions significantly affect the phenotype of immune cells. This study compared, for the first time, the impact of xeno-free human AB serum and xenogeneic fetal bovine serum (FBS) culture conditions on the surface marker expression of monocy…
BackgroundSkin-related adverse events (AEs) induced by apalutamide occur frequently in Japanese patients with prostate cancer. However, biomarkers for predicting these skin-related AEs have not yet been identified. Therefore, this study investigated wh…
Patients with transfusion-dependent thalassemia (TDT) are at high risk of alloimmunization. While previous research is predominantly focused on red blood cell alloimmunization, the potential risks of platelet alloimmunization are frequently underestima…
Macrophage senescence is increasingly recognized as a key contributor to immune dysfunction during aging and chronic inflammation. Here, we developed a reproducible long-term in vitro culture model to investigate the senescence’s phenotypic and functio…
IntroductionUveal melanoma (UM) is the most common primary intraocular malignancy in adults, characterized by high metastatic potential, primarily to the liver. UM exhibits unique molecular drivers, such as GNAQ/GNA11 mutations, and a distinct immune m…
Dengue viruses belong to the genus Flavivirus and consist of a serocomplex of four serotypes (DENV-1, DENV-2, DENV-3, and DENV-4). As arthropod-borne viruses (arboviruses), their transmission is mediated primarily by the vector Aedes aegypti. Antiviral…
BackgroundThe COVID-19 pandemic has highlighted the crucial role of vaccines in preventing infection and reducing disease severity. However, emerging SARS-CoV-2 variants have posed challenges to vaccine-induced immunity.ObjectiveTo evaluate the immunol…
Autoimmune bullous diseases (AIBDs) are acquired disorders characterized by autoantibodies targeting structural proteins of the skin and mucous membranes, resulting in blister formation. In pemphigus, pathogenic autoantibodies primarily directed agains…
Primary cutaneous T cell lymphomas (CTCL) are a heterogeneous group of rare lymphoproliferative disorders originating in the skin. Extracorporeal photopheresis (ECP) is an established, effective and excellently tolerable CTCL therapy, that can also be …
