p38γ and p38δ (p38γ/p38δ) have emerged as important regulators of immune function; however, their specific contribution to adaptive humoral responses remains poorly understood. Based on previous evidence that global p38γ/p38δ deficiency impairs antibod…
Effective risk stratification is vital for donor selection and treatment strategies in allogeneic hematopoietic stem cell transplantation (HSCT). We developed a prediction model for mid- to long-term outcomes after HSCT using a stacked ensemble model (…
BackgroundThe Toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP) is a key adaptor in Toll-like receptor signaling, classically functioning as a cytoplasmic bridging adaptor for Myeloid differentiation primary response 88 (MyD88) recr…
BackgroundpAc/Emm55 (IFx-Hu2.0) is a plasmid DNA therapy encoding a Streptococcus pyogenes-derived bacterial gene. It shows anti-tumor activity in preclinical models, but the mechanisms of anti-melanoma immunity and additive effects with immune checkpo…
BackgroundThe global spread of monkeypox represents a significant public health challenge. Vaccination is the cornerstone of pandemic control, and understanding the psychological factors underlying vaccination decisions is crucial. This study aimed to …
The ability of CD8 T cells to mediate protective immunity while limiting immunopathology depends on critical transcription factors such as Smad4 and Eomes that regulate differentiation of activated CTLs. Disruption of transcriptional programs mediated …
ObjectivesWe assessed the frequency of adverse drureactions (ADRs) to immunoglobulin products, associated switching patterns, and tolerability after switching in clinical practice.MethodsThis observational, retrospective study was conducted at a single…
All living organisms are enclosed by biological membranes composed primarily of phospholipids. The diversification of membrane lipids has shaped key membrane functions, including signaling, membrane protein regulation, and immune responses, and may als…
ObjectivesNeurological involvement is a heterogeneous complication of Sjögren’s disease (SjD). We aimed to describe its prevalence and spectrum, and identify factors associated with peripheral (PNS) and central nervous system (CNS) involvement.MethodsW…
Src family kinases (SFKs) share highly conserved catalytic domains yet display distinct biological functions, raising the question of how substrate specificity is achieved. Here, we investigate the basis of differential ITAM recognition by Lck and Src,…
