Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with poorly understood and complex pathophysiology with interplay between many immune and stromal cells. While the T cell infiltrate in HS is well-documented, the relationship between…
Early developmental stages of teleost fish represent vulnerable phases of the life cycle, characterized by exposure to fluctuating abiotic and biotic environmental conditions. Immune system maturation is gradual, beginning with reliance on maternally t…
BackgroundFamilial adenomatous polyposis (FAP) is a hereditary condition that almost invariably leads to colorectal cancer. While TP53 inactivation is well established as a late event in the adenoma-to-carcinoma sequence, its functional role during the…
Neuro-Behçet syndrome (NBS) is a rare but detrimental neurological manifestation of the Behçet syndrome (BS) – a chronic multisystemic inflammatory disease. NBS is frequently associated with brainstem and spinal cord lesions, often resulting in substan…
ObjectivesIncreased susceptibility to infections is observed in patients with thymomas. These have been invariably attributed to Good syndrome with hypogammaglobulinemia, but there is noticeable heterogeneity in clinical presentation. We clinically and…
BackgroundVitamin D is a pleiotropic steroid hormone with immunomodulatory properties. The role of the active metabolite, 1α,25-dihydroxyvitamin D3 (1,25(OH)2 vitamin D), in regulating human T-cell effector function and immune checkpoint (IC) pathways …
The cGAS/STING pathway is a critical signaling hub that orchestrates type I interferon (IFN) responses, autophagy, and programmed cell death in response to double-stranded DNA (dsDNA) or cyclic dinucleotides. While traditionally characterized as a sens…
Group VIA calcium-independent phospholipaseA2 (iPLA2β or PLA2G6) is a homeostatic enzyme involved in basal glycerophospholipid metabolism. The mutations in the PLA2G6 gene lead to heterogenous neurodegenerative disorders. Global PLA2G6 inactivation in …
Post-herpetic neuralgia (PHN) is a chronic pain condition that persists after shingles and involves dermatome-specific allodynia, disability, and psychological comorbidities. Cutaneous neuroimmune dysregulation is increasingly linked to chronic pain, b…
IntroductionWith the widespread use of biologic agents in dermatology, immune drift has emerged as a growing clinical challenge. Although several case reports suggest the therapeutic potential of JAK inhibitors, clinical evidence for upadacitinib—a hig…
