Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN) are immune-mediated peripheral neuropathies that may follow a progressive course and be refractory and poorly tolerated to standard immunomodulatory …
ObjectivesTo evaluate the therapeutic management of patients with active adult-onset Still’s disease (AOSD) in a multicentre real-world setting and to provide and compare current real-world treatment strategies with existing recent international recomm…
BackgroundAdjuvant treatment of melanoma patients with PD-1-based immunotherapy has improved recurrence rate, and became a standard treatment. However, a considerable proportion of patients recur within 1–2 years, necessitating the identification of pr…
Lysophosphatidylcholines (LPCs) are among the most abundant circulating bioactive lipids, whose fatty acid compositions critically influence their immunomodulatory functions. Alterations in circulating LPC species have been implicated in inflammatory s…
ObjectivesOur aim was to investigate the association between diagnostic delay and the clinical and psychosocial features in patients with psoriatic arthritis (PsA), with particular focus on the mental health, wellbeing, and pain-related mechanisms.Meth…
IntroductionStem cell-derived organoids are promising platforms for therapeutic screening in inflammatory bowel disease (IBD), but identifying functional organoid readouts with translational utility is challenging. Colon epithelial organoids from patie…
Vaccination relies on innate and adaptive responses initiated at the injection site followed by activation in draining lymph nodes. However, high-plex, spatially resolved maps that couple injection site signals with transcriptomic programs in draining …
IntroductionIn human papillomavirus (HPV)-positive oropharyngeal cancer (OPC), lymph node metastasis is common, yet its biological and prognostic implications remain incompletely understood. Less is known about the spatial organization of immune progra…
Eculizumab, a humanized monoclonal antibody targeting the complement protein C5, is highly efficient in paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, generalized myasthenia gravis, and neuromyelitis optica spectrum disorder. …
IntroductionThe updated SOFA-2 score excludes the immune system due to specificity concerns, creating a conceptual gap given that sepsis is defined by a dysregulated host response. We hypothesized that augmenting SOFA-2 with widely available immune mar…
