Invariant natural killer T (iNKT) cells play a role in preventing graft-versus-host disease (GVHD) in bone marrow transplantation (BMT), but it is not known whether and how the NKT10 and NKT17 subsets prevent GVHD. Here, we investigated the anti-GVH ef…
Background and objectivesSerum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP) in neuromyelitis optica spectrum disorder (NMOSD) have recently emerged as potential biomarkers of disease activity, although their clinic…
IntroductionGlobally, 15-30% of patients with chronic hepatitis C develop compensated advanced chronic liver disease (cACLD). cACLD may further advance to decompensated ACLD (dACLD), which is associated with higher liver-related mortality, even after s…
Urinary tract infections (UTIs) are common and traditionally linked to bacteria; however, yeasts— particularly Trichosporon asahii — have emerged as opportunistic pathogens in immunocompromised and hospitalized patients. The presence of fungi may repre…
Thymopoiesis plays a critical role in shaping the peripheral T-cell repertoire during childhood. Following pediatric liver transplantation, patients receive intensive immunosuppressive therapy, which may disrupt thymic function; however, thymic involve…
BackgroundEarly detection of hepatic involvement in common variable immunodeficiency (CVID) and agammaglobulinemia (AGA) remains hampered by the absence of validated non-invasive biomarkers. Although the Enhanced Liver Fibrosis (ELF) score is well esta…
BackgroundInducible nitric oxide synthase (iNOS) and its product nitric oxide (NO) were historically linked to poor melanoma outcomes, yet recent evidence shows NO supports anti-tumor immunity. This study examines how iNOS shapes anti–PD-1 efficacy, pa…
Orbital inflammation is the most common presentation of VEXAS, with any orbital structure potentially affected. Non-sight-threatening and uncomplicated anterior non-granulomatous uveitis and anterior diffuse scleritis follow in frequency, along with ep…
We conducted a retrospective review of adult kidney transplant recipients (KTRs) who received belatacept in addition to calcineurin inhibitors, antimetabolites, and corticosteroids for recurrent or refractory rejection or for persistent donor-specific …
Thrombotic microangiopathies (TMAs) encompass a spectrum of severe pathological conditions mostly characterized by hemolytic anemia, microvascular thrombosis with organ failure, and thrombocytopenia. The etiological spectrum of TMA is diverse, with a n…
