BackgroundImmune checkpoint inhibitors (ICIs) enhance antitumor immunity but can disrupt immune tolerance, leading to immune-related adverse events (irAEs) affecting multiple organs. Simultaneous life-threatening multiorgan irAEs remain rare and poorly…
Managing persistent soft tissue residual disease in high-risk neuroblastoma (HR-NB) remains a clinical challenge, particularly when conventional response assessments suggest remission but residual lesions persist. Determining whether such lesions repre…
Individuals living with HIV/AIDS may be more susceptible to various opportunistic infections due to an immunocompromised status, which can result in diverse clinical manifestations. Among potential pathogens, Mycobacterium colombiense—a slow-growing ba…
Pagetoid reticulosis (PR), also known as Woringer–Kolopp disease (WKD), is a rare subtype of cutaneous T-cell lymphoma. Due to its low incidence and non-specific clinical presentation, it is frequently prone to misdiagnosis. We report the case of a 53-…
ObjectiveEpidermodysplasia verruciformis (EV) is a rare genodermatosis with susceptibility to specific HPVs and risk of malignant transformation. Atypical EV presenting as isolated facial hypopigmented macules closely mimicking pityriasis alba can lead…
WHIM syndrome is a rare primary immunodeficiency disorder caused by gain-of-function mutations of the chemokine receptor CXCR4, leading to abnormal and exacerbated leukocyte trafficking. It is associated with severe neutropenia and lymphopenia, and rec…
Anti-IgLON5 disease is a rare autoimmune neurological disorder characterized by anti- neuronal surface autoantibodies targeting the Immunoglobulin-Like Cell Adhesion Molecule 5 (IgLON5) protein. We report a 53-year-old male patient diagnosed with anti-…
BackgroundGranulomatosis with Polyangiitis (GPA) is an antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis that predominantly affects the upper or lower respiratory tracts and the kidney. While otologic involvement is relatively common in …
Complement component 3 (C3) plays a central role in innate immunity as a convergence point of the classical, alternative, and lectin pathways. Complete C3 deficiency is an extremely rare inborn error of immunity, typically associated with recurrent sev…
Systemic lupus erythematosus (SLE) and paroxysmal nocturnal hemoglobinuria (PNH) represent distinct disorders linked by complement pathway dysregulation, yet their co-occurrence remains poorly characterized. We present a 42-year-old woman with newly di…
