Waldenström macroglobulinemia (WM) is a rare indolent B-cell lymphoma, characterized by lymphoplasmacytic infiltration of bone marrow and the existence of monoclonal IgM in circulation. Renal AL amyloidosis is an uncommon complication of WM, and its tr…
BackgroundAutoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is an autoimmune inflammatory disorder of the central nervous system associated with GFAP-IgG. It most commonly presents as meningoencephalitis, myelitis, or meningoencephalomye…
Inborn defects of the alternative pathway (AP) of the complement system have revealed its essential role in host defense against invasive infections caused by encapsulated bacteria. Biallelic pathogenic variants in the CFB gene cause complement factor …
IntroductionImmune checkpoint inhibitors (ICIs) have transformed the therapeutic landscape of advanced non-small cell lung cancer (NSCLC), offering durable survival in selected patients. However, ICIs can induce immune-related adverse events (irAEs), a…
BackgroundImmunotherapy with checkpoint inhibitor (ICI) has revolutionized the treatment of cancer including squamous cell carcinoma. Nevertheless, there is an unmet need to gain a better understanding of the effect of these therapies on pregnancy and …
Immune checkpoint inhibitor-associated myocarditis, myositis, and myasthenia gravis overlap syndrome (IM3OS) is an uncommon immune-related adverse event (irAE) associated with the use of immune checkpoint inhibitors for the treatment of malignancies. W…
Pyoderma gangrenosum is a rare autoimmune condition that is difficult to diagnose and primarily affects the skin. Extracutaneous manifestations, including hepatic involvement, occur only rarely. Here, we report a case of extracutaneous manifestation of…
Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental condition characterized by impairments in social communication and restricted, repetitive behaviors. Increasing evidence suggests that immune dysregulation may be present in a subset …
BackgroundFebrile infection-related epilepsy syndrome (FIRES) is a severe epileptic encephalopathy with limited treatment options. Neuroinflammation, particularly involving IL-1β and IL-6, is a key driver. Evidence on sequential use of IL-6 receptor bl…
Anti-glomerular basement membrane antibody (anti-GBM) disease is a rare yet aggressive autoimmune disorder that affects the kidneys and lungs. Patients with renal involvement often progressed to death or end-stage renal disease. Treatment with plasmaph…
