Long-term survival after targeted therapy plus immunotherapy without chemotherapy in advanced gallbladder carcinoma: a case report and literature review

BackgroundGallbladder carcinoma (GBC) is a highly aggressive malignancy with limited treatment options and poor prognosis, particularly in advanced stages. Traditional chemotherapy often yields modest outcomes and can be poorly tolerated.Materials and …

Rare subungual amelanotic melanoma presenting as prolonged swelling and exudation after trauma: case report and literature review

BackgroundSubungual amelanotic melanoma (SAM) poses significant diagnostic challenges due to its rarity and nonspecific clinical manifestations, such as nail dystrophy or indurated plaque.Case presentationWe present the case of a 60-year-old woman with…

Case report and literature review: tislelizumab combined with lenvatinib and polymeric micellar paclitaxel for thymic squamous cell carcinoma

Thymic squamous cell carcinoma (TSCC) is a rare malignancy with an annual incidence of 0.15–0.32 per 100,000 population and exhibits aggressive behavior including early metastasis. Anti-PD-1 immunotherapy combined with chemotherapy has emerged as a pot…

Intracranial infections of Candida albicans and Mycobacterium intracellulare associated with CARD9 deficiency: case report and review of literature

BackgroundInvasive candidiasis, most commonly caused by Candida albicans, poses a significant mortality risk and is challenging to treat. Non-tuberculous mycobacterial infections are opportunistic and linked to immune impairment. Caspase recruitment do…

Case Report: A rare case of complex Behçet’s disease complicated with acute tubular necrosis and IgA nephropathy, coexists with myelodysplastic syndrome, trisomy 8 and intestinal involvement

Behçet’s disease (BD) is a rare systemic disease in which small-vessel vasculitis impacts multiple bodily organs. It is typically marked by recurrent oral and genital ulcers, uveitis, and cutaneous lesions. However, peripheral vessels, cardiovascular s…

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