To investigate the efficacy of Iptacopan in transplantation-associated thrombotic microangiopathy (TA-TMA) after allogeneic hematopoietic stem cell transplantation (allo-HSCT), we report the case of a 43-year-old male with Acute Myeloid Leukemia, Myelo…
Eosinophilic granulomatosis with polyangiitis (EGPA) represents a systemic necrotizing vasculitis characterized by prominent peripheral eosinophilia. Concomitant plasma cell dyscrasias in the context of EGPA remain exceedingly rare in clinical literatu…
Immune checkpoint inhibitors (ICIs) have transformed the management of metastatic melanoma, providing durable survival benefits in a subset of patients. However, their use is associated with immune-related adverse events (irAEs), which may be unpredict…
BackgroundImmune checkpoint inhibitors (ICIs) can trigger immune-related adverse events (irAEs), among which Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is exceptionally rare but potentially fatal. Sintilimab, a PD-1 inhibitor increas…
We report on a 38-year-old patient who presented with rapidly progressive interstitial lung disease (ILD), without any signs of muscular involvement. Antinuclear antibody testing by indirect immunofluorescence revealed a nuclear titer of 1:320 with a f…
Locally advanced esophageal squamous cell carcinoma (ESCC) can be treated effectively with surgical resection following downstaging via preoperative neoadjuvant therapy. This case report details the successful management of a patient with ESCC complica…
BackgroundImmune checkpoint inhibitors (ICIs) have significantly improved survival in patients with advanced non-small cell lung cancer (NSCLC), but may rarely trigger severe immune-related adverse events (irAEs).Case summaryA 64-year-oldpatient with m…
IntroductionTumor necrosis factor (TNF)-α inhibitors are widely used for rheumatoid arthritis (RA), but paradoxical immune reactions, including autoimmune thyroid disease, have been reported.Case presentationWe describe a 71-year-old man with a 16-year…
Combined central and peripheral demyelination (CCPD) is a rare chronic demyelinating disorder. Neurofilament (NF) proteins are structural components specific to neuronal intermediate filaments within axons. The presence of anti-neurofilament antibodies…
BackgroundListeria monocytogenes is an uncommon cause of infective endocarditis but is associated with a high morbidity and mortality rate in immunocompromised hosts. Evans syndrome, typically treated with prolonged high-dose corticosteroids and additi…
