BackgroundA combination of local and systemic therapies is used to treat inguinal lymph node metastases post-penile cancer surgery. This multimodal approach may include surgery, chemotherapy, radiotherapy, and immunotherapy.Case summaryWe describe an 8…
BackgroundTuberculosis (TB) remains a leading opportunistic infection in immunocompromised hosts. Disruption of host–pathogen interactions under cumulative immunosuppression may result in atypical extrapulmonary disease with indolent clinical manifesta…
We report an invasive deep-tissue infection caused by Neoscytalidium dimidiatum in a diabetic patient in China. Although typically a phytopathogen restricted to superficial human infections, it caused rapid necrosis necessitating hallux amputation. Thi…
PurposeThe aim of this study was to present a case of early-onset mevalonic aciduria (MA) in a neonate and summarize the relevant phenotypic and genotypic spectra of MA.Methods and resultsWe describe a neonate who presented with elevated inflammatory m…
BackgroundHuman leukocyte antigen (HLA) matching is critical for donor selection in allogeneic hematopoietic stem cell transplantation (allo-HSCT). Each HLA locus is normally biallelic; however, exceptionally rare cases with more than two alleles at a …
This report describes a rare case of neuromyelitis optica spectrum disorder (NMOSD) complicated by systemic capillary leak syndrome (SCLS) and reviews the literature to examine the clinical features, pathogenesis, and therapeutic implications of autoim…
Patient concernsA 69-year-old female presented with hypercalcemia, recurrent fever, and lymphadenectasis following COVID-19 infection. Positron emission tomography/computed tomography (PET-CT) revealed no suspicious malignancy. Lymph node biopsy from b…
Primary undifferentiated pleomorphic sarcoma (UPS) of the renal pelvis is an extremely rare and aggressive mesenchymal malignancy. The diagnosis remains challenged, and its clinical characteristics and treatment strategies remain unclear. Urine fluores…
This case report presents the novel and successful use of periungual Xeligekimab injections for managing refractory Acrodermatitis Continua of Hallopeau (ACH), representing the first documented application of this localized administration route for the…
Adult-onset Still disease (AOSD) is an uncommon autoinflammatory disorder characterized by high spiking fevers, arthralgia, and, classically a transient, salmon-colored rash. Atypical cutaneous variants, such as persistent erythematous papules and plaq…
