BackgroundActivated phosphoinositide 3-kinase delta syndrome (APDS) is a primary immunodeficiency caused by gain-of-function mutations in the PIK3CD gene, leading to dysregulated immune responses. Clinical manifestations include recurrent infections, l…
We here report the first case of subacute combined degeneration (SCD)-mimic accompanying adaptor protein-3B2 (AP3B2) antibody, expanding the clinical spectrum of AP3B2 antibody-associated disorders. A 55-year-old woman presented with progressive limb n…
Rickettsia felis, an emerging flea-borne pathogen with global distribution potential, is a neglected cause of undifferentiated febrile illness, although reported human cases remain sparse. The development of molecular diagnostic methods, along with the…
Mucormycosis is a life-threatening angioinvasive fungal infection caused by the Mucorales acidophilic fungi. In the article we report a case of cutaneous mucosporidiosis caused by infection with Rhizopus arrhizus in a patient with systemic lupus erythe…
Secukinumab is a fully human monoclonal antibody that specifically targets and neutralizes interleukin (IL)-17A, a cytokine typically involved in the mucocutaneous defense against pathogens. Despite its favorable safety profile, serious adverse events …
Neuromyelitis optica spectrum disorder (NMOSD) is an immune-mediated inflammatory demyelinating disease affecting the optic nerve and spinal cord. NMOSD frequently coexists with other autoimmune diseases. However, its concurrence with mixed connective …
BackgroundAutoimmune polyglandular syndrome type 1 (APS-1) is a rare inborn error of immunity caused by mutations in the AIRE gene, typically associated with chronic mucocutaneous candidiasis, hypoparathyroidism, and adrenal insufficiency. We report th…
BackgroundsAutoimmune nodopathies (ANs) with autoantibodies against cell adhesion molecules including contactin-1 (CNTN1) located in the nodes of Ranvier and paranodes have specific clinical features. Patients with anti-CNTN1 AN accompanied by paraneop…
Immunotherapy has emerged as a promising strategy to improve the survival of patients with cancer. This case report presents a patient with unresectable advanced lung squamous cell carcinoma (LSCC) who successfully underwent surgical resection followin…
Guillain–Barré syndrome (GBS) is a rare neurological disorder characterized by muscle weakness and paralysis. Although the exact etiology remains unclear, the current standard treatments include intravenous immunoglobulin (IVIG) and plasma exchange (PL…
