BackgroundImmune checkpoint inhibitors (ICIs) have significantly improved survival in patients with advanced non-small cell lung cancer (NSCLC), but may rarely trigger severe immune-related adverse events (irAEs).Case summaryA 64-year-oldpatient with m…
IntroductionTumor necrosis factor (TNF)-α inhibitors are widely used for rheumatoid arthritis (RA), but paradoxical immune reactions, including autoimmune thyroid disease, have been reported.Case presentationWe describe a 71-year-old man with a 16-year…
Combined central and peripheral demyelination (CCPD) is a rare chronic demyelinating disorder. Neurofilament (NF) proteins are structural components specific to neuronal intermediate filaments within axons. The presence of anti-neurofilament antibodies…
BackgroundListeria monocytogenes is an uncommon cause of infective endocarditis but is associated with a high morbidity and mortality rate in immunocompromised hosts. Evans syndrome, typically treated with prolonged high-dose corticosteroids and additi…
Caplan syndrome is a rare disorder characterized by the coexistence of pneumoconiosis and rheumatoid arthritis (RA), primarily observed in individuals with silica or coal dust exposure. Data on disease behavior in the context of incomplete or irregular…
BackgroundNuclear protein in testis (NUT) carcinoma is an extremely rare and highly aggressive epithelial malignancy driven by NUTM1 rearrangements. Sinonasal involvement is uncommon and often presents with non-specific clinical and radiologic features…
SAPHO syndrome is a rare chronic aseptic inflammatory disorder characterized by the concurrence of osteoarticular inflammation and cutaneous lesions. The intricate mechanism network, coupled with issues such as paradoxical reactions, often results in s…
BackgroundNiemann–Pick type C (NPC) is a lysosomal lipid trafficking disorder that is associated with defective autophagy and impaired bacterial clearance, potentially predisposing patients to Crohn’s disease (CD)-like granulomatous enteritis. Tumor ne…
Giant, ulcerated triple-negative breast cancer (TNBC) presents major therapeutic challenges. We report a 39-year-old woman with a 14.3 cm ulcerated TNBC (cT4bNxM0) who developed infection after intravenous chemotherapy. To achieve rapid local control, …
BackgroundChimeric antigen receptor T (CAR-T) cell therapy is an effective treatment for treatment-refractory hematological disorders with an acceptable safety profile. In contrast, preliminary reports suggest good efficacy for treatment-refractory aut…
