BackgroundVascularized composite allotransplantation (VCA) of the face and limbs restores form and function after devastating injury but, as in other transplant settings, remains limited by the precision of its diagnostic tools. Current surveillance re…
Hidradenitis suppurativa (HS) is a chronic, recurrent inflammatory skin disorder of the pilosebaceous unit, characterized by nodules, abscesses, and sinus tracts formation in apocrine gland-bearing skin. Increasing evidence suggests that HS is not sole…
Immune checkpoint blockade has revolutionized the treatment of lung cancer; however, therapeutic responses remain heterogeneous, particularly in patients harboring activating epidermal growth factor receptor (EGFR) mutations. Emerging evidence identifi…
Inflammatory bowel disease (IBD) is sustained not only by dysregulated adaptive immunity, but also by profound disruption of the intestinal macrophage compartment. In healthy mucosa, macrophages maintain immune tolerance, support epithelial integrity, …
Frailty and multimorbidity are closely intertwined syndromes of later life, yet they are still commonly interpreted through parallel clinical frameworks rather than a shared biological mechanism. In this mini review, we propose that immunosenescence pr…
Inborn errors of immunity comprise a heterogeneous group of disorders characterized by impaired immune function and a high burden of pulmonary complications, which are major contributors to morbidity and mortality. Lung involvement arises primarily thr…
Cell therapies such as chimeric antigen receptor (CAR) T cells and T cell receptor (TCR) T cells marked transformative advances in the treatment of hematologic and solid malignancies, respectively. Thus, adoptive T cell therapy (ACT), in which autologo…
Non-small cell lung cancer (NSCLC), the most prevalent form of lung malignancy, remains a leading cause of cancer-related mortality despite advances in surgery, targeted therapy, and immunotherapy. A growing body of evidence implicates the tumor immune…
Chronic hepatitis B virus (HBV) infection is a major global cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Despite current antiviral therapies, functional cure remains elusive due to persistent HBsAg expression and immune dysfunct…
IntroductionVitiligo is an autoimmune skin disorder driven by CD8+ T cell−mediated melanocyte destruction, in which breakdown of immune tolerance plays a pivotal role. Regulatory T cells (Tregs) are central to maintaining peripheral immune tolerance, b…
