The traditional paradigm of linking single genes to individual phenotypes is being replaced by a systems-level framework to understand the complexity of the tumor microenvironment. In this context, in silico knockout has emerged as a powerful computati…
Mycobacterium tuberculosis (Mtb) secretes the low molecular weight protein tyrosine phosphatase B (PtpB), which disrupts key host innate immune defenses. This review synthesizes current knowledge regarding PtpB, highlighting its unique structural featu…
In recent years, heat stroke (HS) have been reported with increasing frequency, and this trend is hard to separate from broader environmental changes, including climate change, recurrent extreme heat events, and air pollution. When people are exposed t…
Gut-derived metabolites function as critical signaling intermediaries that translate environmental cues into central nervous system (CNS) responses, playing an indispensable role in the pathogenesis and trajectory of neuroimmune inflammatory disorders….
Systemic lupus erythematosus (SLE) is a chronic, complex autoimmune disease arising from the interaction of environmental triggers with a genetically susceptible host. Among environmental factors, infection with Epstein–Barr virus (EBV) has one of the …
Nowadays, the management of chronic obstructive airway diseases is shifting from traditional diagnostic labels toward a precision medicine approach based on “treatable traits.” Among these, blood eosinophilia is emerging as a biomarker of type 2 (T2) i…
White matter changes are a hallmark of aging and neurodegenerative diseases, characterized by progressive myelin deterioration and impaired regenerative capacities. Growing evidence indicates that maladaptive interactions between microglia and infiltra…
Schistosomiasis, caused by blood flukes of the genus Schistosoma, is a neglected tropical disease whose transmission depends on freshwater snails. Oncomelania hupensis is the obligate intermediate host for Schistosoma japonicum, disrupting this snail-s…
Cardiac amyloidosis (CA) is a progressive infiltrative cardiomyopathy most commonly caused by transthyretin (ATTR) or immunoglobulin light chain (AL) amyloid deposition in the myocardium, microvasculature, and conduction system, although rarer forms, i…
Oxidized low-density lipoprotein (oxLDL) is a central driver of inflammatory responses in atherosclerosis and triggers multiple forms of regulated cell death beyond classical apoptosis. Ferroptosis, characterized by iron-dependent lipid peroxidation (L…
