IntroductionBirdshot uveitis (BU) is a chronic, debilitating posterior uveitis strongly associated with HLA-A*29, supporting a suspected autoimmune etiology. We used high-dimensional mass cytometry and clinical stratification to characterize the periph…
BackgroundSepsis-induced acute lung injury (ALI) remains a devastating complication of sepsis, marked by uncontrolled pulmonary inflammation, alveolar-capillary barrier disruption, and high mortality. Ferroptosis, an iron-dependent form of regulated ce…
BackgroundSkin substitutes, also known as Cellular and/or Tissue-based Products (CTPs), and wound dressings often are designed to support the innate wound healing response of the patient. The mechanism of action for these products varies, with some pro…
As domestic silkworm (Bombyx mori) pupae emerge as a promising alternative food source, the severe IgE-mediated allergic reactions they trigger have raised significant public health concerns. Despite the identification of the novel allergen Bombyx mori…
BackgroundOral squamous cell carcinoma (OSCC) is the most prevalent form of oral cancer and is characterized by a poor prognosis and frequent immune evasion. While the tumor microenvironment (TME) plays a central role in modulating responses to therapy…
BackgroundTo explore the clinical characteristics of atezolizumab-associated encephalitis and to provide clinical evidence for diagnosis and treatment.MethodsClinical reports on atezolizumab-associated encephalitis published before June 30, 2026 were c…
Immune responses vary substantially between individuals and populations, reflecting differences in genetics, environment, and cumulative antigenic exposures. Characterizing these exposures, or the immunological exposome, is essential for understanding …
The presence of polymorphonuclear neutrophils (PMNs) in the tumor microenvironment is associated with lower survival rates for cancer patients. Presumably due to the immunosuppressive activity of neutrophils (also known as Myeloid-Derived Suppressor Ce…
Chimeric antigen receptor (CAR)-engineered natural killer (NK) cells represent a promising platform for cancer immunotherapy; however, optimization of CAR architecture and additional engineering strategies remain necessary to improve their functional a…
BackgroundThe ITAM-containing FcRγ chain, encoded by FCER1G, non-covalently couples with the immunoglobulin-binding receptors, — FcγRI (CD64), FcγRIIIa (CD16), FcϵRI and FcαRI (CD89), — to initiate intracellular signals and mediate phagocytosis, cyto…
