IntroductionGaining insights into the molecular features associated with T cell exhaustion (TEX) can offer fresh perspectives on predicting treatment responses, and we aim to investigate TEX-related tumor associated macrophages (TAM) subset to deeply u…
BackgroundThe highly polymorphic Human Leukocyte Antigen (HLA) system is critical for adaptive immunity and determines compatibility in transfusion and transplantation medicine. Admixed Latin American populations, such as Colombia’s trihybrid populatio…
IntroductionThis study aimed to evaluate the prevalence of frailty and to identify its associated risk factors in hospitalized patients with Sjögren’s disease (SjD).MethodsA cross-sectional study was conducted among hospitalized SjD patients at Xuanwu …
BackgroundLung adenocarcinoma (LUAD) represents a major subtype of non-small cell lung cancer with limited therapeutic options. While the ubiquitin-proteasome system has been implicated in cancer pathogenesis, the specific role of deubiquitinating enzy…
IntroductionPANoptosis is a form of inflammatory cell death that exhibits simultaneous activation of pyroptosis, apoptosis and necroptosis signaling. Disulfiram is a clinically used anti-alcoholism drug and can inhibit NLRP3 inflammasome activation and…
BackgroundTuberculosis remains a leading cause of death from infectious diseases globally, underscoring the need to boost innate responses in monocytes and macrophages to enhance early control of Mycobacterium tuberculosis infection. Trained immunity, …
BackgroundThe rising global incidence of clear cell renal cell carcinoma (ccRCC) often coincides with metabolic disorders like type 2 diabetes mellitus (T2DM). However, the association between these two conditions remains unclear. This study aimed to i…
IntroductionTargeting tumor angiogenesis through vascular endothelial growth factor (VEGF) blockade represents a promising strategy for melanoma treatment. Here, we evaluate the therapeutic potential of HEBERSaVax, an anti-VEGF active immunotherapy, in…
BackgroundSerum amyloid A (SAA), an acute-phase pro-inflammatory protein, is overexpressed in several cancers and is involved in shaping pro-tumor responses. We have previously reported that lung cancer stem cells secrete SAA, which contributes to tumo…
IntroductionHepatotoxicity is commonly observed in patients undergoing chemotherapy. However, the clinical features and outcomes of hepatotoxicity associated with anti-neoplastic agents remain unclear. In this study, we investigated the characteristics…
