BackgroundActivated B-cell (ABC) diffuse large B-cell lymphoma (DLBCL) has worse outcomes than the germinal center B-cell (GCB) subtype, but underlying molecular mechanisms remain poorly understood.MethodsTranscriptomic analysis on 43 DLBCL samples (23…
IntroductionXenotransplantation using genetically modified pigs is a promising solution to organ shortages, particularly for highly sensitized patients with broad anti-HLA sensitization who lack compatible allografts. However, preformed human anti-HLA …
IntroductionPsoriasis patients are frequently exposed to residual inflammation and visceral obesity, two factors that synergistically increase cardiometabolic risk.MethodsWe evaluated IL-6 as a potential integrative biomarker linking these pathways in …
IntroductionChimeric Antigen Receptor (CAR)–based therapies have transformed cancer treatment, especially in hematological malignancies. While the impact of co-stimulatory domains on CAR-T cell efficacy is well established, the optimal signaling module…
BackgroundDiffuse large B-cell lymphoma (DLBCL) exhibits immunological heterogeneity that influences outcomes of immunochemotherapy, with CD8+ T cells playing a critical role in patient prognosis.MethodsWe integrated single-cell and bulk transcriptome …
IntroductionBovine viral diarrhea virus (BVDV) is a major pathogen in cattle globally. Nanobodies (Nbs) possess attractive therapeutic properties, but their efficacy against intracellular targets like BVDV is hindered by poor membrane permeability.Meth…
BackgroundHemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening syndrome characterized by immune dysregulation and excessive inflammation. Although diagnostic criteria and treatment protocols of HLH are well-established for pediatric …
BackgroundAtherosclerosis (AS) remains a leading cause of cardiovascular morbidity and mortality, characterized by intricate interactions between immune dysregulation and lipid metabolism abnormalities—identifying key mediators in its pathogenesis is c…
The early phase of drug development relies on the examination of the efficacy and safety of therapeutic agents in animal models. Due to their close genetic and physiological relation to humans, cynomolgus monkeys (Macaca fascicularis) are a promising a…
Streptococcus pneumoniae serotype-3 (ST-3) continues to be a major contributor to pneumococcal disease burden despite its inclusion in multivalent pneumococcal conjugate vaccines (PCV). Therefore, there is a pressing need to develop vaccines that can e…
