IntroductionSevere combined immunodeficiency (SCID) and other profound T- and B-cell lymphopenias are life-threatening conditions that benefit from early diagnosis and treatment. In October 2022, Ukraine launched a nationwide newborn screening (NBS) pr…
BackgroundHLA-C molecules play a critical role in the immune response, particularly in antigen presentation and immune modulation.MethodsTo investigate the effect of the most common HLA-C allotypes on the stability of the HLA-C-β-2 microglobulin-peptid…
ObjectiveTo evaluate the association between serum adalimumab (ADA) concentrations, antibodies against adalimumab (AAAs), tumor necrosis factor α (TNFα) levels, and clinical response in patients with noninfectious uveitis (NIU), as well as changes in T…
Xenopus laevis juvenile frogs regenerate wounded skin without scarring, yet the underlying mechanisms driving this process remain poorly defined. Macrophages are critical to wound repair across vertebrates, and our results indicate a transient influx o…
BackgroundHepatic arterial infusion chemotherapy (HAIC) combined with targeted immunotherapy has emerged as a key therapeutic option for advanced (or unresectable) hepatocellular carcinoma (HCC). Nevertheless, treatment efficacy varies significantly am…
IntroductionAllergic disease is a common and symptomatically heterogeneous group of inflammatory disorders marked by overactive Th2 and mast cell (MC) responses along with eosinophil infiltration. Treatment options require continual assessment due to b…
IntroductionRegulatory T cells (Treg)-based therapies are increasingly used for treating autoimmune or graft-versus-host (GVHD) disease. Given their low frequency, several approaches aimed at amplifying them or at increasing their immunosuppressive act…
Background and aimsHepatitis B virus (HBV) causes chronic hepatic infection, leading to various advanced liver diseases. Currently, there is still a lack of effective non-invasive biomarkers for evaluating hepatic inflammation and fibrosis. Circulating…
AimThis study aimed to assess anti-tetanus IgG antibody levels and identify determinants of inadequate tetanus immunity among maintenance hemodialysis (HD) patients.MethodsIn this cross-sectional study, anti-tetanus IgG levels were measured by quantita…
With antibiotic resistance being a major global concern, there is a huge need of new treatment options to fight bacterial infections. In this study, we highlight the antibacterial and host-protective roles of a novel synthetic antimicrobial peptide in …
