IntroductionAtherosclerosis (AS) is a vascular disorder characterized by lipid accumulation and chronic inflammation, with pathogenesis closely linked to genetic factors and immune regulatory mechanisms.MethodsThis study comprehensively identified ASas…
BackgroundMalignant ascites in high-grade serous ovarian cancer (HGSOC) represent a fluid extension of the tumor microenvironment, embedding immune programs that may inform prognosis and treatment response. We investigated whether ascitic T-cell phenot…
IntroductionLung cancer is a highly heterogeneous disease, and the tumor microenvironment (TME) characteristics are closely related to disease progression and treatment outcomes. We elucidated the cell type-specific transcriptome landscape of cancer ce…
BackgroundCD47 is a “don’t eat me” signal that is overexpressed in tumors to evade phagocytosis by tumor associated macrophages (TAM). Investigational agents targeting CD47, such as magrolimab, aim to induce phagocytosis of tumor cells by TAMs. Previou…
Diffuse large B-cell lymphoma (DLBCL) is one of the most frequent B-cell non-Hodgkin lymphoma types. It is characterized by a complex immune microenvironment, rich in macrophages (innate immunity cells), and high aggressiveness. DLBCL cells might respo…
BackgroundSolid cancer patients are at increased risk of severe COVID-19 and may benefit from repeated booster doses of SARS-CoV-2 mRNA vaccines. Beyond neutralizing antibody titers, recent evidence highlights the induction of spike-specific IgG4 after…
BackgroundBreast cancer poses a severe threat owing to its high morbidity and mortality rates, which are largely attributed to drug resistance. Therefore, novel therapeutic targets need to be identified. Pyroptosis is an inflammatory cell death process…
BackgroundBreast cancer (BC) ranks among the most prevalent malignant tumors in women globally, with mitochondrial dysfunction constituting one of its pathogenic mechanisms.ObjectivesTo investigate the relationship between mitochondrial function-relate…
BackgroundThe contribution of circulating group 3 innate lymphoid cells (ILC3s) to lipid dysregulation has remained poorly defined, and the mechanisms through which washed microbiota transplantation (WMT) improves lipid metabolism require further clari…
BackgroundThe coexistence of allergic rhinitis (AR) and functional constipation (FC) in children reflects complex gut–immune interactions; however, the contribution of microbiota-derived short-chain fatty acids (SCFAs) to immune-metabolic dysregulation…
