ObjectiveIntravenous immunoglobulin (IVIG) resistance in Kawasaki disease (KD) increases the risk of coronary artery lesions (CALs) and the need for additional therapies. Early identification remains a clinical challenge. This study evaluated the predi…
IntroductionIn systemic sclerosis (SSc), the laboratory panel lacks biomarkers able to predict the disease course and/or reflect the fibrotic activity in the skin and internal organs. We assessed the association of the serum levels of urokinase (urokin…
IntroductionThe regulation of CD274 (PD-L1), a pivotal immune checkpoint in cancer immunotherapy, remain incompletely understood. The male-specific lethal (MSL) complex, initially identified in Drosophila dosage compensation, contains the core subunit …
ObjectiveThis study aimed to investigate the correlation between anti-phospholipase A2 receptor (PLA2R) levels in serum and urine with clinical parameters, particularly albuminuria, in patients with idiopathic membranous nephropathy (IMN).MethodsWe ret…
BackgroundLumbar disc degeneration, a primary cause of chronic low back pain, is closely linked to inflammatory responses and the immune microenvironment; however, its underlying mechanisms remain poorly understood.MethodsThis study integrated scRNA-se…
IntroductionAtopic dermatitis (AD) is a chronic inflammatory skin disorder resulting from the interplay of genetic and environmental factors, with a dysregulated type-2 immune response. The association between AD onset and intestinal dysbiosis supports…
BackgroundIt has been reported that HLA was associated with susceptibility to various liver diseases. However, data on HLA in end-stage liver disease (ESLD) patients are limited. Therefore, this study aimed to explore the association of HLA with suscep…
BackgroundLung adenocarcinoma (LUAD) is the most prevalent subtype of lung cancer, with lymph node metastasis serving as a key prognostic factor. MUC5B, a member of the mucin family, has been implicated in the progression of various cancers, yet its sp…
BackgroundGiven the growing interest in the influence of lymph node metastasis on the prognosis of patients diagnosed with pancreatic head cancer (PHC). This study aims to evaluate the ability of current four nodal staging systems predicting long-term …
IntroductionLung adenocarcinoma (LUAD) is a global health threat due to its rapid malignant progression and poor prognosis. Ferroptosis plays a key role in LAUD progression, but the critical ferroptosis-related factors in LUAD have not been further exp…
