BackgroundIntraperitoneal metastasis is a frequent progression in colon cancer, highlighting the critical need for enhanced therapeutic approaches. Oncolytic virus (OV) therapy has emerged as a promising immunotherapeutic strategy. The combination of O…
BackgroundWhile the roles of classical type 2 (T2) inflammatory factors in allergic rhinitis (AR) have been well characterized, the roles of non-classical T2 inflammation factors are less explored. This study aimed to elucidate the roles and predictive…
IntroductionRespiratory infections caused by seasonal influenza viruses remain a major global health burden. Vitamin D receptor (VDR) signaling regulates immune responses, but the role of the VDR and its interaction with parathyroid hormone (PTH) in ho…
BackgroundInflammatory bowel disease (IBD) remains therapeutically challenging, and disruption of the intestinal epithelial barrier constitutes a key pathogenic event. Ginseng-derived vesicle-like nanoparticles (GDNPs) protect against intestinal barrie…
ObjectiveIn this study, machine-learning screening was implemented on human transcriptomic data from public GEO datasets and independent experiments were served to validate candidate biomarkers for sepsis in mice models.MethodsMicroarray data were obta…
BackgroundPeriodontitis (PD) is a prevalent chronic inflammatory disease characterized by periodontal tissue destruction and alveolar bone loss. The contribution of cellular senescence- and circadian rhythm-related genes to PD progression remains incom…
BackgroundThe clinical efficacy of therapeutic cancer vaccines is critically limited by the inefficient in vivo delivery of tumor antigens to dendritic cells (DCs), the key regulators of T-cell immunity.MethodsTo address this issue, we developed a dend…
BackgroundKawasaki disease (KD) diagnosis remains challenging because no pathognomonic test exists and the clinical presentation overlaps extensively with common childhood infections. Acute KD is accompanied by reproducible lipid perturbations, yet whe…
BackgroundR-loop dysregulation has been implicated in chronic inflammation via DNA damage and cytoplasmic ssDNA release, yet its role in acute pancreatitis (AP) remains to be systematically investigated. This study aimed to identify R-loop-related biom…
ObjectiveTo compare FLOT and SOX as chemotherapy backbones for neoadjuvant or conversion immunochemotherapy in gastric cancer, with emphasis on pathological efficacy, treatment-related toxicity, treatment feasibility, postoperative safety, and explorat…
