Background and aimsHepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is associated with high short- and long-term mortality. Prior nucleos(t)ide analogue (NA) treatment history, particularly treatment withdrawal and virological resist…
ObjectivePeripheral immune-inflammatory activity may influence postoperative vascular remodeling in Moyamoya disease (MMD), but the relevant pathways may differ by developmental stage. We investigated age-dependent associations of blood cell-derived in…
BackgroundSelpercatinib is a highly selective rearranged during transfection (RET) receptor tyrosine kinase inhibitor approved for RET fusion-positive cancers and known to penetrate the blood–brain barrier. Although RET signaling has been implicated in…
A significant challenge in the study of neuroimmune responses is the identification and separation of resident microglia from infiltrating bone marrow-derived macrophages. Therefore, we investigated whether dual labelling of Cx3cr1 and Ccr2 is sufficie…
A significant challenge in the study of neuroimmune responses is the identification and separation of resident microglia from infiltrating bone marrow-derived macrophages. Therefore, we investigated whether dual labelling of Cx3cr1 and Ccr2 is sufficie…
IntroductionTrypanosoma cruzi, the causative agent of Chagas disease, enters the host through the skin. While natural killer (NK) cell antimicrobial activity against T. cruzi-infected keratinocytes in the epidermis has previously been shown, NK cell in…
IntroductionTrypanosoma cruzi, the causative agent of Chagas disease, enters the host through the skin. While natural killer (NK) cell antimicrobial activity against T. cruzi-infected keratinocytes in the epidermis has previously been shown, NK cell in…
BackgroundBacterial vaginosis (BV) is a prevalent vaginal dysbiosis primarily associated with Gardnerella vaginalis (G. vaginalis). However, its pathogenic mechanisms remain incompletely understood, particularly the interplay between microbial dysbiosi…
IntroductionNeuroendocrine carcinoma (NEC) of the uterine cervix is a rare and aggressive malignancy for which disease-specific treatment strategies remain limited. Although immune checkpoint inhibitors (ICIs) have demonstrated activity in several canc…
IntroductionNeuroendocrine carcinoma (NEC) of the uterine cervix is a rare and aggressive malignancy for which disease-specific treatment strategies remain limited. Although immune checkpoint inhibitors (ICIs) have demonstrated activity in several canc…
