The adjuvant system AS01 comprised of the TLR4 agonist monophosphoryl lipid A (MPLA) and the saponin QS-21 embedded in liposomes is currently used in recombinant vaccines against shingles, respiratory syncytial virus infection, and malaria. The efficac…
IntroductionTCR-mimetic CAR-T combines antibody-based targeting with physiological TCR signaling, yet suboptimal co-stimulation and safety risks remain key barriers for solid tumor therapy. The prevailing assumption that stronger co-stimulation yields …
Stimulator of interferon genes (STING) is a key player in innate immunity, and its dysregulation has been implicated in autoimmune and inflammatory diseases. The activation of STING is regulated by multiple factors, including post-translational modific…
BackgroundPeriodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome, although not rare, is frequently underdiagnosed. This might be related to the fact that some primary care physicians are not familiar with this syndrome. With th…
BackgroundDermatomyositis (DM) is a systemic autoimmune disease characterized by cutaneous manifestations and inflammatory skeletal muscle injury. Dysregulated type I interferon signaling and regulated cell death pathways may converge to promote myofib…
Kawasaki disease (KD) is an acute pediatric vasculitis with risk of coronary artery injury. A two-transcript IFI27–MCEMP1 score has distinguished KD from other febrile illnesses, but its relationship to long noncoding RNAs (lncRNAs) is incompletely def…
IntroductionLINC00887 plays critical roles in tumor biology, from oncogenesis to metastasis and drug resistance, while the specific mechanism in ccRCC remains unclear. We analyzed the expression profiles of LINC00887 and UPF1 and assessed their correla…
BackgroundPathological complete response (pCR) after neoadjuvant chemoimmunotherapy (NACI) varies among patients with non-small cell lung cancer (NSCLC). This study aimed to quantify intratumoral heterogeneity using habitat analysis and to develop a pr…
BackgroundThymectomy is an established treatment for thymoma-associated myasthenia gravis (MG). However, a subset of patients develop new-onset MG after surgery. Although thymectomy affects immune homeostasis, its comprehensive impact on the peripheral…
Thymocytes upregulate expression of recombination activating genes (RAGs) upon developmental transition from the CD4−CD8− double-negative to the CD4+CD8+ double-positive (DP) stage. Although enhanced RAG expression is necessary to generate a complete T…
